Baton Rouge Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to repair itself before the harm was done. Medical Spine and Sports Injury and Rehab Centers is always amazed at what the body can do! Medical Spine and Sports Injury and Rehab Centers sees its Baton Rouge chiropractic care as a partner of the body’s system in healing particularly when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is showing value in its ability to interrupt the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process during which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a recent study, melatonin boosted autophagy and reduced the degradation of the disc’s extracellular matrix (technically marked by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Medical Spine and Sports Injury and Rehab Centers is encouraged by this research to see just how well melatonin can perform for Baton Rouge back pain linked to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is such a common malady seen at Medical Spine and Sports Injury and Rehab Centers making positive news like this quite rousing. A recent study explained how melatonin could modulate the extracellular matrix of the disc remodeling process initiated by IL-1 β. Further, melatonin decreased the inflammatory cell collection and decreased the release of connected inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin disrupted the IL-1B feedback loop, researchers suggested that melatonin may contribute to the restoration process of intervertebral discs after damage has already been done. (1) Medical Spine and Sports Injury and Rehab Centers continues following the new research on the role inflammation plays in Baton Rouge disc degeneration and melatonin’s role in tackling it.
INFLAMMATION AND MELATONIN
The importance of melatonin in helping to slow or stop painful conditions due to inflammation is growing. The description of melatonin as a multitasking molecule influencing mood, immunity, and energy among other things is quite suitable. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific effect on inflammation and disc degeneration is most attention-getting to Medical Spine and Sports Injury and Rehab Centers and our Baton Rouge back pain patients.
CONTACT Medical Spine and Sports Injury and Rehab Centers
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she illustrates how The Cox® Technic System of Spinal Pain Management handles disc degeneration for relief of chronic low back pain in her patient.
Schedule your Baton Rouge chiropractic appointment with Medical Spine and Sports Injury and Rehab Centers soon. We can talk about how inflammation affects your back pain and how melatonin may address the related disc degeneration.
